Dual mTOR Inhibition Is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma

sun protection devices, sun protection scores (SPUS and SPAS) were created. Points were given for subjects’ responses regarding usage of sunscreen, sunglasses, hats/headgear, or shade structures. Sporadic use received 0 points, occasional use received 1 point, and routine use received 2 points. For statistical analysis, independent sample t-tests assuming unequal variance and χ tests were used for group comparisons when appropriate. Pearson’s correlation coefficient (r) was used for correlation analyses. A multivariate linear/logistic regression model was designed and performed for sun protection use and for sunburns. Two-tailed P-valueso0.05 were considered to be statistically significant. Statistical analyses were carried out using Stata Statistical Software, version 12 (Statacorp, College Station, TX).